Tissue Specific Cytogentetic Instability in Ovarian Epithelial Cells from Women at High Risk of
Ovarian Cancer

Ovarian Cancer: Challenges

Genetic Predisposition to Ovarian Cancer

BRCA Protein Function

Slide 5

Ovarian Cancer and FA Genes

Hypothesis

Experimental Design

FA Diagnosis

Slide 10

FANCD2 Immunoblot Screening

Patient Samples Screened (n=22)

Slide 13

Slide 14

HR and CA Cells Are Breakage Positive
and FANCD2 Corrects Breakage

FANCD2 Complements MMC-Sensitivity
in OSE Cells

FANCD2 RNA is Reduced in Ovarian Samples (but Not Blood)

What Causes Low FANCD2 Expression ?

Summary

Conclusions

Conclusions

Acknowledgments