Mission:  promote ovarian cancer awareness and education; support those diagnosed and survivors; and advocate for public policy and funding.

ca 125 test

CA-125, which stands for “Cancer Antigen 125” is a protein that may be found in high amounts in the blood of patients with ovarian cancer.  CA-125 is produced on the surface of cells and is released in the blood stream.  This protein is elevated in more than 80 percent of women with advanced ovarian cancers, and in 50 percent of those with early-stage cancers.

The CA-125 test is among the blood tests that may be ordered by a doctor if ovarian cancer is suspected.

Because CA-125 misses half of early cancers and can be elevated by benign conditions, such as diverticulitis, endometriosis, liver cirrhosis, pregnancy, and uterine fibroids, the National Cancer Institute and the United States Preventive Services Task Force do not endorse using it to screen women for ovarian cancer who are at ordinary risk or in the general population. Research on new ways to use CA-125 to more accurately identify ovarian cancer is underway.

CA-125, however, is approved by the Food and Drug Administration to monitor the effectiveness of treatment for ovarian cancer and for detecting disease recurrence after treatment.

This information has been taken with permission from the Ovarian Cancer Research Alliance, https://ocrahope.org

According to a booklet issued by the Foundation for Women's Cancer, the "association between ovarian cancer and CA 125 often leads to confusion and misunderstanding about what this test means for diagnosis of ovarian cancer and/or its impact on the clinical management of ovarian cancer."

To address this, the booklet walks through "the basics of what you need to know about CA 125 — what it is, what it’s measuring, and what the values mean."

Read the complete booklet.

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